Regenerating Battle Wounds, Together

Landmarks in Existing Tissue at Wounds Are Utilized to Generate Pattern in Regenerating Tissue

Regeneration in many organisms involves the formation of a blastema, which differentiates and organizes into the appropriate missing tissues. How blastema pattern is generated and integrated with pre-existing tissues is a central question in the field of regeneration. Planarians are free-living flatworms capable of rapidly regenerating from small body fragments [1]. A cell cluster at the anteri...

Metabolic effects of injury; studies of the plasma non-protein nitrogen components in patients with severe battle wounds.

Wounds.

A 23-year-old man living in Orange County, California who was involved in a motor vehicle accident suffered a closed both-bone forearm fracture that was treated with open reduction and internal fixation. The patient then developed wound necrosis and abscesses that revealed a pure culture of non-toxigenic Vibrio cholerae. The wound required debridement and excision, which was followed by split-t...

Regenerating Wnts

Research in recent years challenged what we once thought of as the canonical function of signaling proteins to reveal new and surprising mechanisms of action. Morphogens, like Wnts, BMPs, or SHHs, long thought to be the factors that provide positional information to specify cell fate and proliferation have turned out to be as important for synaptogenesis, axonal growth, and guidance during both...

Regenerating Perfection.